Ibuprofen is one of those drugs that resides in medicine cabinets all over the globe, its
familiarity having become its greatest weakness.
It is used like a glass of water, frequently, casually, and without much thought to the
actual effects it is having, beyond the obvious relief it is providing from the current
distress.
The familiarity with the drug is certainly warranted, but from a renal standpoint, the
actual effects it is having are worthy of a much more honest discussion than the
packaging would suggest.


The actual method by which the drug works is important, however, because it explains
everything.
Ibuprofen, an NSAID, works by inhibiting prostaglandins, which are chemical messengers that, among other duties, are responsible for controlling blood flow to the
kidneys.

Normally, in a well-hydrated, healthy individual, the kidneys do not depend too greatly
on prostaglandins to ensure an adequate blood supply to the kidneys themselves.

However, in states of physiological stress, dehydration, decreased cardiac output,
existing kidney disease, and old age, prostaglandins are extremely important to ensure
an adequate blood supply to the kidneys, and the inhibition of such can result in a
significant reduction in the blood supply to the kidneys, a phenomenon known as acute
kidney injury, which can occur in a matter of hours from the time the drug was ingested.

More info...
https://www.quora.com/Is-ibuprofen-bad-for-the-kidneys

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Mike,

Ibuprofen is one of those drugs that resides in medicine
cabinets all over the globe, its familiarity having become its
greatest weakness. It is used like a glass of water,
frequently, casually, and without much thought to the actual
effects it is having, beyond the obvious relief it is providing
from the current distress.

The only pain killer I have here is acetomenaphin 500 milligram
tablets. Even taking one of these will knock me out.

Daryl

... Fotoflagellation - The act of waving a Polaroid so it develops faster.
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However, in states of physiological stress, dehydration, decreased
cardiac output,
existing kidney disease, and old age, prostaglandins are extremely important to ensure
an adequate blood supply to the kidneys, and the inhibition of such can result in a
significant reduction in the blood supply to the kidneys, a phenomenon known as acute
kidney injury, which can occur in a matter of hours from the time the
drug was ingested

Over a decade ago I had been sick and dehydrated, I ended up in the ER with severe rib pain when trying to breath, they gave me an anti-inflammatory intravenously. Less than 12 hours later I was back in the ER with kidney failure. It was acute and considered medically educed. While I no longer take pain meds in part due to that experience, I'd say in general with any medication I am more careful to read the label and or question the potential side effects prior to consuming it.

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On 3/31/2026 4:50 PM, The Godfather wrote to Mike Dippel:

Over a decade ago I had been sick and dehydrated, I ended up in the ER with severe rib pain when trying to breath, they gave me an anti-inflammatory intravenously. Less than 12 hours later I was back in the ER with kidney failure. It was acute and considered medically educed. While I no longer take
pain meds in part due to that experience, I'd say in general with any medication I am more careful to read the label and or question the potential side effects prior to consuming it.

Thanks for sharing.

I sometimes ask the pharmacist when I am picking up and new prescription to explain
the med and ask what time of day it should be taken, as well as does this medication
conflict with the other meds.

You can never know too much when ir comes to prescription drugs.

BTW. Welcome back. It's been a while.

Mike Dippel

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